SCHEMBL692939

SCHEMBL692939

Cc1cc(C)cc(Oc2ccc(C#N)cc2N)c1

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
AR P10275 4/20 0.51
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
GAA P10253 1/20 0.41
TBXA2R P21731 4/20 0.40
USP2 O75604 1/20 0.40
CYP2A6 P11509 1/20 0.38
HTR2A P28223 1/20 0.38
SLC6A4 P31645 1/20 0.38
KCNH2 Q12809 1/20 0.38
VEGFA P15692 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2819246 0.81 MAPT (0.47) ARALDH1A1SMN1; SMN2L3MBTL1GAA
SCHEMBL2033412 0.81 EPAS1 (0.44) ARVEGFA
SCHEMBL31090835 0.80 CYP1A2 (0.57) ARALDH1A1SMN1; SMN2GAASLC6A4
SCHEMBL7129140 0.80 CYP1A2 (0.57) ARALDH1A1SMN1; SMN2GAASLC6A4
SCHEMBL28021493 0.79 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2L3MBTL1GAAUSP2
SCHEMBL693880 0.78 AR (0.51) ARALDH1A1L3MBTL1CYP2A6SLC6A4
SCHEMBL27718911 0.78 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2L3MBTL1GAAUSP2
SCHEMBL810984 0.77 AR (0.48) ARALDH1A1SMN1; SMN2
SCHEMBL7020181 0.77 AR (0.46) ARALDH1A1SMN1; SMN2L3MBTL1USP2
SCHEMBL921658 0.75 ALDH1A1 (0.59) ARALDH1A1SMN1; SMN2CYP2A6SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102459210-B Arylsulfonamide ccr3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-09-02 CN disclosed
EP-2502921-B1 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS INC (US) 2015-05-20 EP disclosed
EP-2502921-B1 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS INC (US) 2015-05-20 EP disclosed
US-8999995-B2 Isotopically enriched arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-04-07 US disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-08-22 US disclosed
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-08-22 US disclosed
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-08-22 US disclosed
US-8420639-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-04-16 US disclosed
US-8420639-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-04-16 US disclosed
EP-2502921-A1 Arylsulfonamide CCR3 antagonists Axikin Pharmaceuticals, Inc. (US) 2012-09-26 EP disclosed
EP-2502921-A1 Arylsulfonamide CCR3 antagonists Axikin Pharmaceuticals, Inc. (US) 2012-09-26 EP disclosed
EP-2421838-A2 ARYLSULFONAMIDE CCR3 ANTAGONISTS Axikin Pharmaceuticals, Inc. (US) 2012-02-29 EP disclosed
US-20100273795-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 US disclosed
US-20100273795-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 US disclosed
US-20100273795-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 US disclosed
WO-2010123960-A2 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 WO disclosed
WO-2010123960-A2 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100273795-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 AR 1322/4885ALDH1A1 2454/4885SMN1; SMN2 642/4885
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 AR 1322/4885ALDH1A1 2454/4885SMN1; SMN2 642/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.