Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.48 |
| ▸ | PRKDC | P78527 | 8/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.48 |
| ▸ | SRC | P12931 | 6/20 | 0.48 |
| ▸ | ABL1 | P00519 | 5/20 | 0.48 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | HCK | P08631 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | MTOR | P42345 | 5/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | ATG7 | O95352 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 4/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926274 | 0.84 | PIK3CD (0.52) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10261070 | 0.82 | SRC (0.52) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16864520 | 0.79 | PIK3CD (0.54) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6924506 | 0.79 | PIK3CD (0.49) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6926807 | 0.78 | PIK3CD (0.52) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL868521 | 0.78 | DYRK3 (0.51) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19476278 | 0.78 | ADORA2A (0.49) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6925165 | 0.74 | SRC (0.58) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29780889 | 0.72 | SRC (0.64) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24735059 | 0.72 | SRC (0.56) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | PIK3CD 725/4885PRKDC 762/4885PIK3CA 459/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | PIK3CD 725/4885PRKDC 762/4885PIK3CA 459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.