Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.52 |
| ▸ | PRKDC | P78527 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | HCK | P08631 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 7/20 | 0.44 |
| ▸ | FYN | P06241 | 3/20 | 0.44 |
| ▸ | ATG7 | O95352 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929476 | 0.84 | PIK3CD (0.48) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL16864520 | 0.82 | PIK3CD (0.54) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL10261498 | 0.80 | PIK3CD (0.53) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL16386311 | 0.79 | XDH (0.38) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL6924506 | 0.79 | PIK3CD (0.49) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL6925165 | 0.78 | SRC (0.58) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL868744 | 0.78 | PIK3CD (0.51) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL15826969 | 0.78 | PIK3CD (0.51) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL1741570 | 0.76 | PIK3CD (0.46) | PIK3CDPRKDCKDRPIK3CAPIK3CB | |
| SCHEMBL24735059 | 0.75 | SRC (0.56) | PIK3CDPRKDCKDRPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210332057-A1 | AMINONORBORNANE DERIVATIVE AND MANUFACTURE METHOD THEREFOR AND USE THEREOF | TRANSTHERA SCIENCES (NANJING), INC. (CN) | 2021-10-28 | — | — | US | disclosed |
| US-20180179210-A1 | Inhibitors of the TEC Kinase Enzyme Family | PHARMASCIENCE INC. (CA) | 2018-06-28 | — | — | US | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | PIK3CD 725/4885PRKDC 762/4885KDR 3297/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | PIK3CD 725/4885PRKDC 762/4885KDR 3297/4885 |
| US-20210332057-A1 | AMINONORBORNANE DERIVATIVE AND MANUFACTURE METHOD THEREFOR AND USE THEREOF | BTK, LCK, SYK | PIK3CD 307/4885PRKDC 144/4885KDR 1518/4885 |
| US-20180179210-A1 | Inhibitors of the TEC Kinase Enzyme Family | TEC, BTK, LCK | PIK3CD 245/4885PRKDC 42/4885KDR 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.