Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11222461 | 0.86 | PLCG1 (0.52) | ALDH1A1LMNAPLCG1CA2GAA | |
| SCHEMBL57438 | 0.85 | CA12 (0.45) | ALDH1A1LMNACA2GAATSHR | |
| SCHEMBL9182366 | 0.81 | PLCG1 (0.44) | ALDH1A1LMNAPLCG1CA2GAA | |
| SCHEMBL27649868 | 0.79 | PLCG1 (0.45) | PLCG1CA2GAATSHRMMP2 | |
| SCHEMBL19523745 | 0.78 | GAA (0.44) | PLCG1CA2GAAMMP2MMP1 | |
| SCHEMBL6601720 | 0.78 | GAA (0.44) | LMNAPLCG1CA2GAATSHR | |
| SCHEMBL3386673 | 0.77 | PLCG1 (0.48) | PLCG1CA2GAAMMP2MMP1 | |
| SCHEMBL19229836 | 0.76 | CA2 (0.46) | ALDH1A1PLCG1CA2GAATSHR | |
| SCHEMBL2564478 | 0.75 | CYP3A4 (0.46) | ALDH1A1GAATSHRCA12CA9 | |
| SCHEMBL10433465 | 0.75 | PLCG1 (0.39) | ALDH1A1PLCG1CA2GAAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518282-B1 | Treatment of pruritic dermatoses including allergic dermatitis and atopy in animals and humans | PFIZER INC. | 2003-02-11 | — | — | US | disclosed |
| EP-1072595-A2 | 4-arylpiperidine derivatives for the treatment of pruritus | PFIZER INC. (US) | 2001-01-31 | — | — | EP | disclosed |