Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.58 |
| ▸ | ERN1 | O75460 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6395129 | 0.80 | ALDH3A1 (0.67) | ALDH3A1TP53HTTHCAR3ALDH1A1 | |
| SCHEMBL28886073 | 0.80 | ERN1 (0.57) | ALDH3A1ERN1TP53HTTHCAR3 | |
| SCHEMBL4749290 | 0.79 | ERN1 (0.50) | ALDH3A1ERN1TP53HTTALDH1A1 | |
| SCHEMBL6819324 | 0.79 | ALDH3A1 (0.55) | ALDH3A1TP53HTTHCAR3ALDH1A1 | |
| SCHEMBL14964150 | 0.79 | ALDH3A1 (0.50) | ALDH3A1TP53HTTHCAR3ALDH1A1 | |
| SCHEMBL29951605 | 0.78 | ALDH1A1 (0.54) | ALDH3A1ERN1TP53HTTHCAR3 | |
| SCHEMBL1579080 | 0.76 | IGF1R (0.52) | ALDH3A1ALDH1A1MAPTPOLB | |
| SCHEMBL1579082 | 0.76 | ALDH3A1 (0.43) | ALDH3A1TP53HTTHCAR3ALDH1A1 | |
| SCHEMBL1579081 | 0.76 | IGF1R (0.52) | ALDH3A1ALDH1A1MAPTPOLB | |
| SCHEMBL13357839 | 0.74 | ALDH3A1 (0.46) | ALDH3A1TP53HTTHCAR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |