Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.48 |
| ▸ | HTR2B | P41595 | 14/20 | 0.48 |
| ▸ | HTR2A | P28223 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2575196 | 0.87 | HTR2C (0.57) | HTR2CHTR2BHTR2AMEN1GAA | |
| SCHEMBL2576035 | 0.85 | HTR2C (0.43) | HTR2CHTR2BHTR2A | |
| SCHEMBL692986 | 0.85 | HTR2C (0.46) | HTR2CHTR2BHTR2AMEN1GAA | |
| SCHEMBL2562086 | 0.84 | HTR2C (0.52) | HTR2CHTR2BHTR2AMEN1GAA | |
| SCHEMBL2016949 | 0.82 | HTR2C (0.45) | HTR2CHTR2BHTR2A | |
| SCHEMBL2572371 | 0.80 | HTR2C (0.50) | HTR2CHTR2BHTR2AMEN1GAA | |
| SCHEMBL2566042 | 0.79 | HTR7 (0.44) | HTR2CHTR2BHTR2AMEN1GAA | |
| SCHEMBL14714341 | 0.78 | HTR2C (0.53) | HTR2CHTR2BHTR2AMEN1GAA | |
| SCHEMBL691496 | 0.76 | HTR2C (0.61) | HTR2CHTR2BHTR2AMEN1GAA | |
| SCHEMBL2017936 | 0.74 | HTR2C (0.60) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | claimed |
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |