Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831380 | 0.99 | HSD11B1 (0.43) | HSD11B1HSD17B1HSD17B2CRHR1TSPO | |
| SCHEMBL5830977 | 0.95 | HSD11B1 (0.44) | HSD11B1HSD17B1HSD17B2CRHR1TSPO | |
| SCHEMBL5831130 | 0.90 | HSD11B1 (0.37) | HSD11B1HSD17B1HSD17B2CRHR1NPC1 | |
| SCHEMBL5830489 | 0.87 | HSD11B1 (0.38) | HSD11B1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL5831702 | 0.85 | HSD11B1 (0.41) | HSD11B1HSD17B1HSD17B2CRHR1NPC1 | |
| SCHEMBL5830785 | 0.82 | HSD11B1 (0.42) | HSD11B1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL3621399 | 0.82 | HSD11B1 (0.64) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL6929895 | 0.81 | CRHR1 (0.37) | HSD11B1HSD17B1HSD17B2CRHR1KMT2A | |
| SCHEMBL5831400 | 0.81 | KMT2A (0.42) | HSD11B1HSD17B1HSD17B2CRHR1KMT2A | |
| SCHEMBL3248368 | 0.80 | HSD11B1 (0.41) | HSD11B1HSD17B1HSD17B2CRHR1TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113310-A1 | USE OF AN INHIBITOR OF 11-B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPOUNDS FOR PROMOTING WOUND HEALING | BIOVITRUM AB (SE) | 2004-12-29 | — | — | WO | disclosed |