Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 8/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | CES2 | O00748 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | CASP7 | P55210 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,8-Naphthalic Anhydride SCHEMBL29351054 | 0.97 | TYMS (1.00) | TYMSALDH1A1CES2BCHECES1 | |
| 1,8-Naphthalic Anhydride SCHEMBL30415 | 0.97 | TYMS (1.00) | TYMSALDH1A1CES2BCHECES1 | |
| 1,8-Naphthalic Anhydride SCHEMBL11692800 | 0.95 | TYMS (0.95) | TYMSALDH1A1CES2BCHECES1 | |
| 1,8-Naphthalic Anhydride SCHEMBL10012400 | 0.93 | TYMS (0.91) | TYMSALDH1A1CES2BCHECES1 | |
| 1,8-Naphthalic Anhydride SCHEMBL29143033 | 0.89 | TYMS (0.83) | TYMSALDH1A1CES2BCHECES1 | |
| 1,8-Naphthalic Anhydride SCHEMBL21046340 | 0.89 | TYMS (0.83) | TYMSALDH1A1CES2BCHECES1 | |
| 1,8-Naphthalic Anhydride SCHEMBL7932111 | 0.85 | TYMS (0.76) | TYMSALDH1A1CES2BCHECES1 | |
| 1,8-Naphthalic Anhydride SCHEMBL10012771 | 0.85 | TYMS (0.76) | TYMSALDH1A1CES2BCHECES1 | |
| SCHEMBL15119577 | 0.84 | TYMS (0.75) | TYMSALDH1A1CES2BCHECES1 | |
| SCHEMBL9114473 | 0.83 | TYMS (0.74) | TYMSALDH1A1CES2BCHECES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-A4 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1051655-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | Ista Pharmaceuticals, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999039238-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | KERATOFORM, INC. (US) | 1999-08-05 | — | — | WO | disclosed |