SCHEMBL6929985

SCHEMBL6929985

CC1CC2CC(C)C(NC(=O)c3ccc(OCc4ccccc4)nc3)C(C1)C2

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 1/20 0.46
GABRA5 P31644 7/20 0.46
CHRNB2 P17787 1/20 0.44
CHRNA7 P36544 1/20 0.44
CHRNA4 P43681 1/20 0.44
EPHX2 P34913 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6930956 0.88 CXCR2 (0.51) CXCR2GABRA5CHRNB2CHRNA7CHRNA4
SCHEMBL6930968 0.88 EPHX2 (0.53) CXCR2GABRA5CHRNB2CHRNA7CHRNA4
SCHEMBL6930882 0.85 CXCR2 (0.48) CXCR2GABRA5CHRNB2CHRNA7CHRNA4
SCHEMBL6931414 0.82 CHRNB2 (0.49) CXCR2GABRA5CHRNB2CHRNA7CHRNA4
SCHEMBL6927995 0.77 GABRA5 (0.47) CXCR2GABRA5CHRNB2CHRNA7CHRNA4
SCHEMBL12465248 0.77 CHRNB2 (0.48) CXCR2GABRA5CHRNB2CHRNA7CHRNA4
SCHEMBL6929953 0.76 GABRA5 (0.55) CXCR2GABRA5CHRNB2CHRNA7CHRNA4
SCHEMBL6930206 0.74 GABRA5 (0.64) CXCR2GABRA5
SCHEMBL6930892 0.74 GABRA5 (0.64) GABRA5
SCHEMBL6929807 0.73 GABRA5 (0.64) GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011035324-A1 O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS VANDERBILT UNIVERSITY (US) 2011-03-24 WO disclosed