Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12535906 | 0.74 | ALDH1A1 (0.53) | POLBTP53SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL9965992 | 0.71 | TP53 (0.51) | POLBTP53SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL9570044 | 0.71 | ALDH1A1 (0.53) | POLBTP53SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL16136315 | 0.71 | TP53 (0.58) | TP53SMN1; SMN2HTTL3MBTL1TSHR | |
| SCHEMBL12338477 | 0.71 | ALDH1A1 (0.53) | TP53SMN1; SMN2HTTL3MBTL1TSHR | |
| SCHEMBL4764484 | 0.71 | NPC1 (0.56) | POLBTP53SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL12531819 | 0.71 | SMN1; SMN2 (0.53) | POLBTP53SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL23571793 | 0.70 | NPC1 (0.60) | POLBTP53SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL14131227 | 0.70 | SMN1; SMN2 (0.49) | POLBTP53SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL12631459 | 0.70 | SMN1; SMN2 (0.52) | POLBTP53SMN1; SMN2HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |