Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 3/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | GSK3A | P49840 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.47 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | GAK | O14976 | 2/20 | 0.45 |
| ▸ | STK16 | O75716 | 2/20 | 0.45 |
| ▸ | BMP2K | Q9NSY1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928888 | 0.88 | GSK3A (0.64) | MAPK8MAPK10MAPK14GSK3AGSK3B | |
| SCHEMBL7134630 | 0.84 | ULK1 (0.58) | ULK1MAPK8MAPK10MAPK14GSK3A | |
| SCHEMBL6928950 | 0.82 | ULK1 (0.51) | ULK1MAPK8MAPK10MAPK14GSK3A | |
| SCHEMBL26393949 | 0.77 | ULK1 (0.55) | ULK1GSK3AGSK3BAAK1PIK3CD | |
| Hydrochloric Acid SCHEMBL26129341 | 0.77 | ULK1 (0.54) | ULK1GSK3AGSK3BAAK1PIK3CD | |
| SCHEMBL26396687 | 0.76 | ULK1 (0.56) | ULK1GSK3AGSK3BAAK1PIK3CD | |
| SCHEMBL26396531 | 0.76 | ULK1 (0.56) | ULK1GSK3AGSK3BAAK1PIK3CD | |
| SCHEMBL26396705 | 0.76 | ULK1 (0.56) | ULK1GSK3AGSK3BAAK1PIK3CD | |
| Hydrochloric Acid SCHEMBL26127100 | 0.76 | ULK1 (0.55) | ULK1GSK3AGSK3BAAK1PIK3CD | |
| Hydrochloric Acid SCHEMBL26129521 | 0.76 | ULK1 (0.55) | ULK1GSK3AGSK3BAAK1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | claimed |
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |