Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12806939 | 0.76 | PIM3 (0.51) | PIM3PIM2L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL3083301 | 0.74 | PIM3 (0.54) | PIM3PIM2L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL13283350 | 0.68 | PIM3 (0.57) | PIM3PIM2MAPTSMN1; SMN2MEN1 | |
| SCHEMBL13529492 | 0.67 | L3MBTL1 (0.43) | PIM3PIM2L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL4364406 | 0.65 | BCHE (0.41) | SMN1; SMN2HTTLMNAKDM4EALDH1A1 | |
| SCHEMBL22860003 | 0.65 | — | — | |
| SCHEMBL17595984 | 0.64 | KDM4E (0.37) | LMNAKDM4EALDH1A1USP2 | |
| SCHEMBL20239461 | 0.64 | PIM3 (0.74) | PIM3PIM2L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL1520694 | 0.64 | PIM3 (0.74) | PIM3PIM2L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL23088305 | 0.63 | SELE (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |