Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL157612 | 0.97 | — | — | |
| Pyrrolidine SCHEMBL27968527 | 0.94 | ALDH1A1 (0.44) | ALDH1A1CXCR4SMN1; SMN2HSD17B10KDM4E | |
| Piperidine SCHEMBL476425 | 0.94 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2HSD17B10KDM4E | |
| Piperidine SCHEMBL27755341 | 0.94 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2HSD17B10KDM4E | |
| Pyrrolidine SCHEMBL14815975 | 0.94 | ALDH1A1 (0.44) | ALDH1A1CXCR4SMN1; SMN2HSD17B10KDM4E | |
| Piperidine SCHEMBL1396086 | 0.94 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2HSD17B10KDM4E | |
| Pyrrolidine SCHEMBL14815556 | 0.94 | ALDH1A1 (0.44) | ALDH1A1CXCR4SMN1; SMN2HSD17B10KDM4E | |
| Pyrrolidine SCHEMBL1478729 | 0.94 | ALDH1A1 (0.44) | ALDH1A1CXCR4SMN1; SMN2HSD17B10KDM4E | |
| Piperidine SCHEMBL27925102 | 0.94 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2HSD17B10KDM4E | |
| Piperidine SCHEMBL27977836 | 0.92 | ALDH1A1 (0.50) | ALDH1A1CXCR4SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030181495-A1 | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor | MEDINOX, INC. | 2003-09-25 | — | — | US | disclosed |
| US-6596770-B2 | Disulfide derivative of a dithiocarbamate is coadministered with an agent that inactivates (or inhibits the production of)the species that induce the expression of nitric oxide synthase | MEDINOX, INC. | 2003-07-22 | — | — | US | disclosed |
| EP-1089723-A4 | THERAPEUTIC METHODS EMPLOYING DISULFIDE DERIVATIVES OF DITHIOCARBAMATES AND COMPOSITIONS USEFUL THEREFOR | MEDINOX INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6589991-B1 | Treating diseases associated with nuclear factor kappa B pathway; nitric oxide synthase inhibitors, antiinflammatory agents | MEDINOX, INC. | 2003-07-08 | — | — | US | disclosed |
| US-20020151540-A1 | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor | MEDINOX, INC. | 2002-10-17 | — | — | US | disclosed |
| US-6316502-B1 | ADMINISTERING DISULFIDE DERIVATIVE OF DITHIOCARBAMATE COMPOUND TO BIND TO IRON | MEDINOX, INC. | 2001-11-13 | — | — | US | disclosed |
| CN-1315856-A | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor | MEDINOX INC (US) | 2001-10-03 | — | — | CN | disclosed |
| US-6274627-B1 | ADMINISTERING COMPOUNDS SUCH AS N-METHYL-D-GLUCAMINE DITHIO-CARBAMATE DISULFIDE FOR IN VIVO REDUCTION OF FREE RADICAL LEVELS IN A SUBJECT | MEDINOX, INC. | 2001-08-14 | — | — | US | disclosed |
| EP-1089723-A1 | THERAPEUTIC METHODS EMPLOYING DISULFIDE DERIVATIVES OF DITHIOCARBAMATES AND COMPOSITIONS USEFUL THEREFOR | Medinox, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| US-6093743-A | FOR IN VIVO REDUCTION OF LEVELS OF NITRIC OXIDE, SUCH AS ARE INDUCED BY A VARIETY OF DISEASE STATES, AND FOR TREATMENT OF INFECTIOUS AND/OR INFLAMMATORY CONDITIONS | MEDINOX INC. (US) | 2000-07-25 | — | — | US | disclosed |
| WO-1999066918-A9 | THERAPEUTIC METHODS EMPLOYING DISULFIDE DERIVATIVES OF DITHIOCARBAMATES AND COMPOSITIONS USEFUL THEREFOR | MEDINOX INC (US) | 2000-03-30 | — | — | WO | disclosed |
| WO-1999066918-A1 | THERAPEUTIC METHODS EMPLOYING DISULFIDE DERIVATIVES OF DITHIOCARBAMATES AND COMPOSITIONS USEFUL THEREFOR | MEDINOX, INC. (US) | 1999-12-29 | — | — | WO | disclosed |