Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952182 | 1.00 | TSHR (0.40) | TSHRTHRBDNM1SIRT2GAA | |
| SCHEMBL15663023 | 1.00 | TSHR (0.40) | TSHRTHRBDNM1SIRT2GAA | |
| SCHEMBL1083484 | 0.90 | TSHR (0.32) | TSHRTHRB | |
| SCHEMBL956338 | 0.89 | TSHR (0.35) | TSHRTHRBSIRT2 | |
| SCHEMBL2496312 | 0.86 | CETP (0.32) | TSHRTHRBSIRT2 | |
| Ethylene Glycol SCHEMBL7118182 | 0.82 | LMNA (0.38) | TSHRTHRBSIRT2GAAALDH1A1 | |
| Ethylene Glycol SCHEMBL5667972 | 0.82 | LMNA (0.38) | TSHRTHRBSIRT2GAAALDH1A1 | |
| Ethylene Glycol SCHEMBL1509039 | 0.80 | LMNA (0.37) | TSHRTHRBSIRT2GAAALDH1A1 | |
| Ethylene Glycol SCHEMBL8416280 | 0.80 | LMNA (0.37) | TSHRTHRBSIRT2GAAALDH1A1 | |
| SCHEMBL790521 | 0.78 | MEN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852140-B1 | METHODS FOR MAKING HARDLY SOLUBLE MEDICINE AMORPHOUS | NISSAN CHEMICAL IND LTD (JP) | 2003-12-03 | — | — | EP | disclosed |
| EP-1356807-A2 | Method for converting sparingly water-soluble medical substance to amorphous state | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-6462093-B1 | Method for converting sparingly water-soluble medical substance to amorphous state | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2002-10-08 | — | — | US | disclosed |
| EP-0852140-A1 | METHODS FOR MAKING HARDLY SOLUBLE MEDICINE AMORPHOUS | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1998-07-08 | — | — | EP | disclosed |