⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18172055 | 0.77 | GAA (0.46) | — | |
| SCHEMBL29793294 | 0.77 | CXCL8 (0.55) | — | |
| SCHEMBL396120 | 0.77 | CXCL8 (0.55) | — | |
| SCHEMBL30912304 | 0.77 | RAB9A (0.54) | — | |
| SCHEMBL29706541 | 0.74 | — | — | |
| SCHEMBL6703503 | 0.74 | — | — | |
| SCHEMBL25077910 | 0.74 | GAA (0.47) | — | |
| SCHEMBL17073475 | 0.72 | — | — | |
| SCHEMBL358526 | 0.72 | — | — | |
| SCHEMBL307353 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 290 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890386-A | Pharmaceutical composition | 阵列生物制药公司 | 2019-06-14 | — | — | CN | claimed |
| CN-109762026-A | A kind of fluorine-containing phenanthrenequione skeleton asymmetry alpha-diimine nickel (II) complex and preparation method and application | 常州大学 | 2019-05-17 | — | — | CN | claimed |
| CN-109503499-A | A kind of Fan get Ta Ni intermediate and preparation method thereof | 南京天越星生物技术有限公司 | 2019-03-22 | — | — | CN | claimed |
| CN-109456272-A | The preparation of mek inhibitor and preparation comprising mek inhibitor | 阵列生物制药公司 | 2019-03-12 | — | — | CN | claimed |
| CN-109354569-A | A kind of preparation method of the bromo- 4- fluorobenzene of 1,3- bis- | 常州大学 | 2019-02-19 | — | — | CN | claimed |
| CN-109336824-A | The preparation of mek inhibitor and preparation comprising mek inhibitor | 诺华股份有限公司 | 2019-02-15 | — | — | CN | claimed |
| CN-109053818-A | The preparation of fluorinated alpha-diimine nickel (II) complex replaced containing ortho position benzhydryl for vinyl polymerization | 常州大学 | 2018-12-21 | — | — | CN | claimed |
| CN-104870427-B | Preparation of and formulations comprising MEK inhibitors | 诺华股份有限公司 | 2018-10-23 | — | — | CN | claimed |
| CN-104487089-B | The combination treatment of mek inhibitor and IGFIR inhibitor | 诺华股份有限公司 | 2018-08-28 | — | — | CN | claimed |
| CN-106905168-B | A kind of method for selective synthesis of the bromo- 2- fluoroanilines of 4- | 青岛科技大学 | 2018-08-10 | — | — | CN | claimed |
| CN-102558243-B | Preparation method of alkyl-substituted 1,10-phenanthroline complex and application of complex prepared thereby as catalyst | SINOPEC CORP. (CN) | 2014-10-22 | — | — | CN | claimed |
| CN-102558242-B | Preparation of isobutyryl substituted 1,10-phenanthroline complex and application of complex serving as catalyst | SINOPEC CORP. (CN) | 2014-10-22 | — | — | CN | claimed |
| CN-103012144-B | Preparation method of flurbiprofen axetil | HARBIN PHARMACEUTICAL GROUP TECHNOLOGY CT | 2014-09-10 | — | — | CN | claimed |
| CN-103965120-A | Quinoline and quinazoline derivative, preparation method, intermediate, composition and application | SHANGHAI PHARMACEUTICALS HOLDING CO LTD | 2014-08-06 | — | — | CN | claimed |
| CN-103804428-A | Preparation method and application of complex | CHINA PETROLEUM & CHEMICAL | 2014-05-21 | — | — | CN | claimed |
| CN-103764144-A | Synergistic combination of a PI3K inhibitor and a MEK inhibitor | NOVARTIS AG | 2014-04-30 | — | — | CN | claimed |
| CN-103694700-A | Preparation method of nano-cable-connected ternary composite electrode material | UNIV BOHAI | 2014-04-02 | — | — | CN | claimed |
| CN-103483276-A | Preparation method of vandetanib impurity | NANJING H & D PHARMACEUTICAL TECHNOLOGY CO LTD | 2014-01-01 | — | — | CN | claimed |
| CN-103380137-A | N ortho acyl substituted nitrogen-containing heterocyclic compound and process for preparing aminal iron (ii) complexes thereof | CHINA PETROLEUM & CHEMICAL | 2013-10-30 | — | — | CN | claimed |
| CN-101945870-B | 5-anilinoimidazopyridines and methods of use | GENENTECH INC | 2012-10-03 | — | — | CN | claimed |