Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.79 |
| ▸ | FLT3 | P36888 | 3/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 2/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetramethylscutellarein SCHEMBL739115 | 0.88 | MEN1 (1.00) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL10031424 | 0.85 | FLT3 (0.84) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1976673 | 0.85 | MEN1 (0.79) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| Salvigenin SCHEMBL1427018 | 0.84 | FLT3 (1.00) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1742322 | 0.83 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| Trimethylapigenin SCHEMBL29350875 | 0.82 | ABCB1 (1.00) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| Trimethylapigenin SCHEMBL1421585 | 0.82 | ABCB1 (1.00) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL17258307 | 0.82 | MEN1 (0.78) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| Ladanein SCHEMBL737069 | 0.81 | FLT3 (0.81) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL6926027 | 0.81 | ABCB1 (0.64) | MEN1KMT2AALDH1A1FLT3ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007528-B1 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | ADVANCED LIFE SCIENCES INC (US) | 2003-11-26 | — | — | EP | disclosed |
| US-6225481-B1 | REACTING 6-IODO-5,7,4'-TRIMETHOXYFLAVONE AND 5,7-4'-TRIMETHOXY-3'-(TRIMETHYLSTANNYL)FLAVONE IN PRESENCE OF PALLADIUM COMPOUND AND BASE TO PRODUCE ROBUSTAFLAVONE HEXAMETHYL ETHER, DEMETHYLATING TO PRODUCE ROBUSTAFLAVONE | ADVANCED LIFE SCIENCES, INC. | 2001-05-01 | — | — | US | disclosed |
| EP-1007528-A2 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | MEDICHEM RESEARCH, INC. (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010292-A2 | ROBUSTAFLAVONE, INTERMEDIATES AND ANALOGUES AND METHOD FOR PREPARATION THEREOF | MEDICHEM RESEARCH, INC. (US) | 1999-03-04 | — | — | WO | disclosed |