Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PER2 | O15055 | 1/20 | 0.43 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.43 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073188 | 1.00 | MAOA (0.52) | MAOAMAOBDRD2ALDH1A1XBP1 | |
| SCHEMBL8173197 | 0.91 | HTT (0.56) | MAOAMAOBALDH1A1XBP1HTT | |
| SCHEMBL12269560 | 0.80 | ALDH1A1 (0.53) | MAOAMAOBALDH1A1 | |
| SCHEMBL13253319 | 0.78 | MAOA (0.63) | MAOAMAOBDRD2ALDH1A1XBP1 | |
| SCHEMBL2464800 | 0.77 | CA1 (0.49) | MAOAMAOBDRD2ALDH1A1HTT | |
| SCHEMBL12124885 | 0.77 | MAOA (0.67) | MAOAMAOBDRD2ALDH1A1XBP1 | |
| SCHEMBL7117305 | 0.76 | MAOA (0.60) | MAOAMAOBDRD2ALDH1A1XBP1 | |
| SCHEMBL17571693 | 0.76 | MAOA (0.60) | MAOAMAOBALDH1A1XBP1HTT | |
| SCHEMBL31572064 | 0.76 | MAOA (0.60) | MAOAMAOBALDH1A1XBP1HTT | |
| SCHEMBL16356395 | 0.76 | MAOA (0.60) | MAOAMAOBALDH1A1XBP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915087-B1 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-04-02 | — | — | EP | disclosed |
| US-6015822-A | ANTIULCER, ANTIDIARRHEA, AND ANTIARRHYTHMIA AGENTS; CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-01-18 | — | — | US | disclosed |
| EP-0915087-A2 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-12 | — | — | EP | disclosed |