Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | G6PD | P11413 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Kynurenine SCHEMBL4577458 | 0.88 | KDM4E (0.68) | KDM4EHIF1ATDP1KYNUSLC1A3 | |
| SCHEMBL17641540 | 0.87 | KDM4E (1.00) | KDM4EHIF1ATDP1G6PDCASP7 | |
| SCHEMBL30973707 | 0.87 | KDM4E (1.00) | KDM4EHIF1ATDP1G6PDCASP7 | |
| SCHEMBL16616577 | 0.87 | KDM4E (1.00) | KDM4EHIF1ATDP1G6PDCASP7 | |
| SCHEMBL29375641 | 0.87 | KDM4E (1.00) | KDM4EHIF1ATDP1G6PDCASP7 | |
| SCHEMBL29934345 | 0.87 | KDM4E (1.00) | KDM4EHIF1ATDP1G6PDCASP7 | |
| SCHEMBL134058 | 0.87 | KDM4E (1.00) | KDM4EHIF1ATDP1G6PDCASP7 | |
| SCHEMBL180582 | 0.87 | KDM4E (1.00) | KDM4EHIF1ATDP1G6PDCASP7 | |
| SCHEMBL29352838 | 0.87 | KDM4E (1.00) | KDM4EHIF1ATDP1G6PDCASP7 | |
| Water SCHEMBL8081334 | 0.86 | KDM4E (0.97) | KDM4EHIF1ATDP1G6PDCASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369114-A1 | Use of tryptophan metabolites as pharmaceutical agents | Terness, Peter, Priv. Doz. Dr. (DE) | 2003-12-10 | — | — | EP | disclosed |