Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3571825 | 0.97 | KDM4E (0.52) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL1590061 | 0.93 | ALDH1A1 (0.55) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL3564213 | 0.92 | KDM4E (0.50) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL11967633 | 0.90 | CASP3 (0.44) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL3561171 | 0.89 | KDM4E (0.59) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL2253345 | 0.86 | CA12 (0.55) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL1590089 | 0.84 | ALDH1A1 (0.51) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL3561086 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL3560451 | 0.83 | ALDH1A1 (0.44) | KDM4EALDH1A1RECQLGAAHPGD | |
| SCHEMBL2299912 | 0.83 | PTGER4 (0.47) | KDM4EALDH1A1RECQLGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368312-A1 | BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064564-A1 | BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2002-08-22 | — | — | WO | disclosed |