Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15059636 | 0.81 | SMN1; SMN2 (0.54) | RAB9AMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL6933367 | 0.80 | XPO1 (0.54) | KCNK3KCNK9RAB9AMEN1KMT2A | |
| SCHEMBL12764065 | 0.78 | KCNK3 (0.83) | KCNK3KCNK9RAB9AMEN1KMT2A | |
| SCHEMBL1124906 | 0.75 | NR1H2 (0.62) | KCNK3KCNK9MEN1KMT2AGAA | |
| SCHEMBL259364 | 0.75 | MEN1 (0.75) | KCNK3KCNK9RAB9AMEN1KMT2A | |
| SCHEMBL259352 | 0.72 | MEN1 (0.72) | KCNK3KCNK9RAB9AMEN1KMT2A | |
| SCHEMBL31424193 | 0.72 | MEN1 (0.72) | KCNK3KCNK9RAB9AMEN1KMT2A | |
| SCHEMBL14308003 | 0.72 | MEN1 (0.66) | KCNK3KCNK9RAB9AMEN1KMT2A | |
| SCHEMBL259303 | 0.72 | PRKCI (0.69) | KCNK3KCNK9RAB9AMEN1KMT2A | |
| SCHEMBL2439309 | 0.72 | GABRP (0.42) | CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114275-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-09-22 | — | — | WO | disclosed |