Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27990974 | 0.83 | AURKB (0.52) | — | |
| SCHEMBL15059195 | 0.82 | AURKB (0.50) | SMN1; SMN2NPC1RAB9AHPGDHTT | |
| SCHEMBL6933361 | 0.81 | KCNK3 (0.55) | SMN1; SMN2NPC1RAB9AHPGDHTT | |
| SCHEMBL15059132 | 0.79 | — | — | |
| SCHEMBL15059678 | 0.77 | — | — | |
| SCHEMBL259364 | 0.76 | MEN1 (0.75) | SMN1; SMN2NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL16201838 | 0.76 | EGFR (0.51) | SMN1; SMN2NPC1RAB9ACDK8EGFR | |
| SCHEMBL6935345 | 0.76 | MEN1 (0.70) | SMN1; SMN2NPC1RAB9AHTTGAA | |
| SCHEMBL259352 | 0.74 | MEN1 (0.72) | SMN1; SMN2NPC1RAB9AHPGDPKM | |
| SCHEMBL31424193 | 0.74 | MEN1 (0.72) | SMN1; SMN2NPC1RAB9AHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794569-B1 | HETEROCYCLIC UREA COMPOUNDS | BIOTA EUROPE LTD (GB) | 2017-05-10 | — | — | EP | disclosed |
| EP-2794569-B1 | HETEROCYCLIC UREA COMPOUNDS | BIOTA EUROPE LTD (GB) | 2017-05-10 | — | — | EP | disclosed |
| US-9060515-B2 | Heterocyclic urea compounds | BIOTA EUROPE LTD. (GB) | 2015-06-23 | — | — | US | disclosed |
| US-9060515-B2 | Heterocyclic urea compounds | BIOTA EUROPE LTD. (GB) | 2015-06-23 | — | — | US | disclosed |
| US-9060515-B2 | Heterocyclic urea compounds | BIOTA EUROPE LTD. (GB) | 2015-06-23 | — | — | US | disclosed |
| US-20140323486-A1 | HETEROCYCLIC UREA COMPOUNDS | SPERO GYRASE, INC. | 2014-10-30 | — | — | US | disclosed |
| US-20140323486-A1 | HETEROCYCLIC UREA COMPOUNDS | SPERO GYRASE, INC. | 2014-10-30 | — | — | US | disclosed |
| US-20140323486-A1 | HETEROCYCLIC UREA COMPOUNDS | SPERO GYRASE, INC. | 2014-10-30 | — | — | US | disclosed |
| EP-2794569-A1 | HETEROCYCLIC UREA COMPOUNDS | Biota Europe Ltd (GB) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013091011-A1 | HETEROCYCLIC UREA COMPOUNDS | BIOTA EUROPE LTD (GB) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013091011-A1 | HETEROCYCLIC UREA COMPOUNDS | BIOTA EUROPE LTD (GB) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323486-A1 | HETEROCYCLIC UREA COMPOUNDS | UMPS, URB2, UROD | SMN1; SMN2 3938/4885NPC1 2664/4885RAB9A 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.