Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 16/20 | 0.44 |
| ▸ | PPARG | P37231 | 16/20 | 0.44 |
| ▸ | PPARD | Q03181 | 13/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934429 | 0.85 | PPARA (0.58) | PPARAPPARGPPARDLTB4RNR1H2 | |
| SCHEMBL7074267 | 0.82 | PPARA (0.61) | PPARAPPARGPPARDLTB4RNR1H2 | |
| SCHEMBL6934021 | 0.81 | PPARG (0.42) | PPARAPPARGPPARDLTB4RNR1H2 | |
| SCHEMBL6934237 | 0.78 | PPARG (0.42) | PPARAPPARGPPARD | |
| SCHEMBL6559278 | 0.76 | PPARG (0.43) | PPARAPPARGPPARDNR1H2NR1H3 | |
| SCHEMBL6559359 | 0.76 | PPARG (0.51) | PPARAPPARGPPARDNR1H2NR1H3 | |
| SCHEMBL6939543 | 0.73 | PPARG (0.58) | PPARAPPARGPPARDLTB4RNR1H2 | |
| SCHEMBL7074261 | 0.72 | PPARG (0.57) | PPARAPPARGPPARDLTB4RNR1H2 | |
| SCHEMBL6931405 | 0.72 | PPARD (0.69) | PPARAPPARGPPARDLTB4RNR1H2 | |
| SCHEMBL6938259 | 0.71 | LTB4R (0.52) | PPARAPPARGPPARDLTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | claimed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |