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SCHEMBL6934142

SCHEMBL6934142

CCCc1ccc(S(=O)(=O)Nc2nc(-c3ccc(NC(=O)CC(C(=O)N(C(C)C)C(C)C)c4nsc(NS(=O)(=O)c5c(Cl)cc(Cl)cc5Cl)n4)cc3)ns2)cc1

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ FBP1 P09467 1/20 0.35
▸ MEN1 O00255 5/20 0.34
▸ KMT2A Q03164 5/20 0.34
▸ POLB P06746 2/20 0.34
▸ JAK2 O60674 1/20 0.34
▸ KLKB1 P03952 1/20 0.34
▸ CTSB P07858 1/20 0.34
▸ ELANE P08246 1/20 0.34
▸ USP36 Q9P275 2/20 0.34
▸ LMNA P02545 2/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6934136 0.84 MEN1 (0.40) MEN1KMT2APOLBLMNAMAPT
SCHEMBL5832283 0.75 AKT1 (0.51) MEN1KMT2APOLBUSP36LMNA
SCHEMBL5831228 0.72 MEN1 (0.59) MEN1KMT2APOLBLMNAKDM4E
SCHEMBL5831678 0.70 AKT1 (0.44) MEN1KMT2ALMNAKDM4E
SCHEMBL5830785 0.69 HSD11B1 (0.42) MEN1KMT2APOLBLMNAKDM4E
SCHEMBL5831430 0.68 USP36 (0.52) MEN1KMT2AUSP36LMNA
SCHEMBL5831645 0.67 MEN1 (0.55) MEN1KMT2APOLBLMNAKDM4E
SCHEMBL5832095 0.65 ATM (0.62) MEN1KMT2APOLBJAK2USP36
SCHEMBL5831692 0.65 BACE1 (0.43) MEN1KMT2ALMNAKDM4EMAPT
SCHEMBL5830489 0.65 HSD11B1 (0.38) MEN1KMT2APOLBLMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004113310-A1 USE OF AN INHIBITOR OF 11-B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPOUNDS FOR PROMOTING WOUND HEALING BIOVITRUM AB (SE) 2004-12-29 — — WO disclosed