Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | CHUK | O15111 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | MARK3 | P27448 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | AKT2 | P31751 | 2/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.48 |
| ▸ | NEK2 | P51955 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934470 | 0.85 | CHEK1 (0.43) | CHEK1AURKACHUKDAPK3JAK2 | |
| Hydrochloric Acid SCHEMBL3499092 | 0.84 | CHEK1 (0.43) | CHEK1AURKACHUKDAPK3JAK2 | |
| SCHEMBL7047330 | 0.83 | FURIN (0.46) | CHEK1AURKACHUKDAPK3JAK2 | |
| SCHEMBL6930688 | 0.83 | KMT2A (0.62) | MEN1KMT2ATDP1POLBALDH1A1 | |
| SCHEMBL14747833 | 0.82 | L3MBTL1 (0.53) | CHEK1AURKACHUKDAPK3JAK2 | |
| SCHEMBL6931409 | 0.80 | MAPT (0.56) | MEN1KMT2APOLBALDH1A1NPC1 | |
| SCHEMBL5973957 | 0.79 | MEN1 (0.60) | MEN1KMT2ACA5APOLBALDH1A1 | |
| SCHEMBL2000342 | 0.78 | MEN1 (0.49) | MEN1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL8886794 | 0.76 | MEN1 (0.47) | MEN1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL5973857 | 0.76 | CHEK1 (0.64) | CHEK1AURKACHUKDAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865434-B1 | COMPOUNDS AND THEIR USE TO TREAT INFECTIOUS DISEASES | PICOWER INST MED RES (US) | 2003-12-17 | — | — | EP | claimed |
| EP-0865434-B1 | COMPOUNDS AND THEIR USE TO TREAT INFECTIOUS DISEASES | PICOWER INST MED RES (US) | 2003-12-17 | — | — | EP | disclosed |
| CN-1098070-C | Guanylhydrazones for treating inflammatory conditions | PICOWER INST MED RES (US) | 2003-01-08 | — | — | CN | disclosed |
| EP-0746312-A4 | GUANYLHYDRAZONES FOR TREATING INFLAMMATORY CONDITIONS | PICOWER INST MED RES (US) | 1999-05-26 | — | — | EP | disclosed |
| CN-1144480-A | Guanylhydrazones for treating inflammatory conditions | PICOWER INST MED RES (US) | 1997-03-05 | — | — | CN | disclosed |
| EP-0746312-A1 | GUANYLHYDRAZONES FOR TREATING INFLAMMATORY CONDITIONS | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995019767-A1 | GUANYLHYDRAZONES FOR TREATING INFLAMMATORY CONDITIONS | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 1995-07-27 | — | — | WO | disclosed |