Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693201 | 0.84 | DRD2 (0.46) | KDM4EALDH1A1APPMAPTPTGER4 | |
| SCHEMBL694150 | 0.83 | GPR52 (0.42) | GPR52KDM4EALDH1A1GAALMNA | |
| SCHEMBL25403980 | 0.80 | KDM4C (0.53) | GPR52PTGER4 | |
| SCHEMBL30585021 | 0.80 | KDM4C (0.53) | GPR52PTGER4 | |
| SCHEMBL6840338 | 0.80 | KDM4C (0.53) | GPR52PTGER4 | |
| SCHEMBL1853743 | 0.80 | GPR52 (0.52) | GPR52KDM4EALDH1A1GAALMNA | |
| SCHEMBL1852926 | 0.80 | GPR52 (0.52) | GPR52KDM4EALDH1A1GAALMNA | |
| SCHEMBL19475067 | 0.78 | PARP1 (0.51) | — | |
| SCHEMBL30585008 | 0.78 | HDAC6 (0.54) | GPR52PTGER4 | |
| SCHEMBL25401936 | 0.77 | GPR52 (0.48) | GPR52KDM4EGAAABHD6PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |