Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 10/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934432 | 0.84 | SMN1; SMN2 (0.61) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL21096166 | 0.82 | KMT2A (0.56) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL15705171 | 0.82 | NPC1 (0.62) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL6874915 | 0.81 | NPC1 (0.69) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL17741237 | 0.79 | BACE1 (0.43) | SMN1; SMN2P4HTMBACE1BACE2 | |
| SCHEMBL16006837 | 0.77 | RAB9A (0.66) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL31277715 | 0.77 | NPC1 (0.63) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL18707493 | 0.76 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL21096059 | 0.76 | SMN1; SMN2 (0.70) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL14658652 | 0.76 | NPC1 (0.61) | NPC1ALDH1A1GAARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009943-A1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |