Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934432 | 0.83 | SMN1; SMN2 (0.61) | KMT2ALMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL15886256 | 0.82 | BACE1 (0.60) | KMT2ARAB9ANPC1SMN1; SMN2GRM4 | |
| SCHEMBL6934524 | 0.82 | NPC1 (0.56) | KMT2ARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL6874915 | 0.80 | NPC1 (0.69) | KMT2ARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL21595576 | 0.78 | SMN1; SMN2 (0.56) | KMT2ARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL30763098 | 0.78 | SMN1; SMN2 (0.56) | KMT2ARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL4115554 | 0.77 | MEN1 (0.59) | KMT2ALMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL17668487 | 0.77 | LMNA (0.42) | KMT2ALMNAP4HTMGRM4BACE1 | |
| SCHEMBL31277715 | 0.76 | NPC1 (0.63) | KMT2ARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL16006837 | 0.76 | RAB9A (0.66) | KMT2ALMNARAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855469-B1 | 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-06-19 | — | — | EP | disclosed |