Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935374 | 1.00 | ADA (0.46) | ADAHTR6MCHR1LTB4RLTB4R2 | |
| SCHEMBL6941459 | 0.83 | ADA (0.52) | ADAHTR6MCHR1LTB4RLTB4R2 | |
| SCHEMBL6941454 | 0.83 | ADA (0.52) | ADAHTR6MCHR1LTB4RLTB4R2 | |
| SCHEMBL6939460 | 0.82 | HTR2A (0.46) | MEN1KMT2A | |
| SCHEMBL6939466 | 0.82 | HTR2A (0.46) | MEN1KMT2A | |
| SCHEMBL6938182 | 0.82 | ADA (0.69) | ADAHTR6ABCG2 | |
| SCHEMBL7848478 | 0.81 | TRPM8 (0.56) | MEN1KMT2AMAPT | |
| SCHEMBL7837654 | 0.79 | HTR1D (0.46) | MEN1KMT2APPARGMAPT | |
| SCHEMBL6939242 | 0.78 | BCL2 (0.46) | ADAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL6939234 | 0.78 | BCL2 (0.46) | ADAMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596738-B1 | Inhibiting activity to adenosine deaminase (hereinafter described as ADA) An adenosine deaminase inhibiting agent comprising a compound of the formula (I): | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |