Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939466 | 1.00 | HTR2A (0.46) | HTR2AGPR84KDM4EHSD17B10HPGD | |
| SCHEMBL6935381 | 0.82 | ADA (0.46) | KMT2AMEN1 | |
| SCHEMBL6935374 | 0.82 | ADA (0.46) | KMT2AMEN1 | |
| SCHEMBL6938178 | 0.79 | TK1 (0.40) | KDM4EHPGDSLC6A4KMT2AMEN1 | |
| SCHEMBL6938174 | 0.79 | TK1 (0.40) | KDM4EHPGDSLC6A4KMT2AMEN1 | |
| SCHEMBL6937603 | 0.77 | HTR2A (0.58) | HTR2AGPR84KDM4EHSD17B10HPGD | |
| SCHEMBL6937592 | 0.77 | HTR2A (0.58) | HTR2AGPR84KDM4EHSD17B10HPGD | |
| SCHEMBL6935332 | 0.77 | ADA (0.57) | HTR2AKDM4EHSD17B10HPGDKMT2A | |
| SCHEMBL7836552 | 0.75 | KDM4E (0.40) | HTR2AKDM4EHSD17B10HPGDKMT2A | |
| SCHEMBL6171832 | 0.74 | DHFR (0.41) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596738-B1 | Inhibiting activity to adenosine deaminase (hereinafter described as ADA) An adenosine deaminase inhibiting agent comprising a compound of the formula (I): | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |