Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938674 | 0.85 | KMT2A (0.39) | ITGB3ITGA2BPARP1PARP10ALDH1A1 | |
| SCHEMBL6934969 | 0.79 | ITGB3 (0.51) | ITGB3ITGA2BPARP1PARP10ITGAV | |
| SCHEMBL30083944 | 0.75 | ITGB3 (0.51) | ITGB3ITGA2BPARP1PARP10ITGAV | |
| SCHEMBL7879691 | 0.75 | ITGB3 (0.56) | ITGB3ITGA2BPARP1PARP10ITGAV | |
| SCHEMBL18271386 | 0.73 | ITGB3 (0.49) | ITGB3ITGA2BPARP1PARP10ITGAV | |
| SCHEMBL7315631 | 0.72 | ITGB3 (0.50) | ITGB3ITGA2BPARP1PARP10ITGAV | |
| SCHEMBL6938684 | 0.70 | ITGB3 (0.43) | ITGB3ITGA2BPARP1PARP10ITGAV | |
| SCHEMBL18269210 | 0.70 | ITGB3 (0.48) | ITGB3ITGA2BPARP1PARP10ITGAV | |
| SCHEMBL7452316 | 0.70 | ITGB3 (0.57) | ITGB3ITGA2BPARP1PARP10PLK4 | |
| SCHEMBL9335947 | 0.70 | ITGB3 (0.69) | ITGB3ITGA2BPARP1ITGAVPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326403-B1 | CARDIOVASCULAR DISORDERS | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-12-04 | — | — | US | claimed |
| EP-1097127-B1 | DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6326403-B1 | CARDIOVASCULAR DISORDERS | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-12-04 | — | — | US | disclosed |