SCHEMBL6934969

SCHEMBL6934969

N=C(N)Nc1cccc(C(=O)NC(=O)NN[C@@H](CC(=O)O)C(N)=O)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 6/20 0.51
ITGA2B P08514 3/20 0.51
ITGAV P06756 3/20 0.46
PARP1 P09874 2/20 0.42
PARP10 Q53GL7 1/20 0.42
HPGDS O60760 2/20 0.39
NPC1 O15118 4/20 0.38
RAB9A P51151 4/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
F3 P13726 2/20 0.38
CASR P41180 1/20 0.37
ALDH1A1 P00352 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
HPGD P15428 1/20 0.37
ALOX12 P18054 1/20 0.37
PLK4 O00444 1/20 0.37
CHEK1 O14757 1/20 0.37
AURKA O14965 1/20 0.37
CHUK O15111 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7879691 0.93 ITGB3 (0.56) ITGB3ITGA2BITGAVPARP1PARP10
SCHEMBL6941352 0.85 ITGB3 (0.47) ITGB3ITGA2BITGAVHPGDSSMN1; SMN2
SCHEMBL7099306 0.85 ITGB3 (0.51) ITGB3ITGA2BITGAVPARP1PARP10
SCHEMBL7104882 0.81 ITGB3 (0.51) ITGB3ITGA2BITGAVPARP1PARP10
SCHEMBL7100982 0.81 ITGB3 (0.51) ITGB3ITGA2BITGAVPARP1PARP10
SCHEMBL7104753 0.81 ITGB3 (0.51) ITGB3ITGA2BITGAVPARP1PARP10
SCHEMBL6938684 0.81 ITGB3 (0.43) ITGB3ITGA2BITGAVPARP1PARP10
SCHEMBL30083944 0.80 ITGB3 (0.51) ITGB3ITGA2BITGAVPARP1PARP10
SCHEMBL6935740 0.79 ITGB3 (0.46) ITGB3ITGA2BITGAVPARP1PARP10
SCHEMBL7105223 0.77 ITGB3 (0.55) ITGB3ITGA2BITGAVNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097127-B1 DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS MERCK PATENT GMBH (DE) 2003-03-12 EP claimed
US-6326403-B1 CARDIOVASCULAR DISORDERS MERCK PATENT GESELLSCHAFT MIT (DE) 2001-12-04 US claimed
EP-1097127-A1 DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS MERCK PATENT GmbH (DE) 2001-05-09 EP claimed
WO-2000003973-A1 DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS MERCK PATENT GMBH (DE) 2000-01-27 WO claimed
EP-1097127-B1 DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS MERCK PATENT GMBH (DE) 2003-03-12 EP disclosed
US-6326403-B1 CARDIOVASCULAR DISORDERS MERCK PATENT GESELLSCHAFT MIT (DE) 2001-12-04 US disclosed
EP-1097127-A1 DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS MERCK PATENT GmbH (DE) 2001-05-09 EP disclosed
WO-2000003973-A1 DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS MERCK PATENT GMBH (DE) 2000-01-27 WO disclosed