Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 5/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935766 | 1.00 | OPRD1 (0.42) | OPRD1OPRM1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6935769 | 1.00 | OPRD1 (0.42) | OPRD1OPRM1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6935960 | 0.86 | OPRD1 (0.56) | OPRD1OPRM1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6937850 | 0.84 | CYP3A4 (0.61) | OPRD1OPRM1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6937847 | 0.84 | CYP3A4 (0.61) | OPRD1OPRM1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6937843 | 0.84 | CYP3A4 (0.61) | OPRD1OPRM1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6935563 | 0.79 | CNR2 (0.40) | OPRD1OPRM1LMNAMAPT | |
| SCHEMBL12017981 | 0.74 | OPRD1 (0.67) | OPRD1OPRM1CYP1A2CYP3A4OPRK1 | |
| SCHEMBL4577098 | 0.74 | OPRD1 (0.67) | OPRD1OPRM1CYP1A2CYP3A4OPRK1 | |
| SCHEMBL6935970 | 0.74 | CYP3A4 (0.63) | OPRD1OPRM1CYP1A2CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649414-B1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | ARDENT PHARMACEUTICALS INC (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-0649414-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993015062-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-05 | — | — | WO | disclosed |