Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2751545 | 0.88 | OPRD1 (0.43) | OPRD1OPRM1MEN1KMT2ALMNA | |
| SCHEMBL6935970 | 0.88 | CYP3A4 (0.63) | OPRD1OPRM1CYP3A4CYP1A2MEN1 | |
| SCHEMBL5300451 | 0.87 | OPRD1 (0.72) | OPRD1OPRM1CYP3A4CYP1A2MEN1 | |
| SCHEMBL6935764 | 0.86 | OPRD1 (0.42) | OPRD1OPRM1CYP3A4CYP1A2MEN1 | |
| SCHEMBL6935766 | 0.86 | OPRD1 (0.42) | OPRD1OPRM1CYP3A4CYP1A2MEN1 | |
| SCHEMBL6935769 | 0.86 | OPRD1 (0.42) | OPRD1OPRM1CYP3A4CYP1A2MEN1 | |
| SCHEMBL6932938 | 0.86 | OPRD1 (0.67) | OPRD1OPRM1CYP3A4CYP1A2MEN1 | |
| SCHEMBL6932934 | 0.86 | OPRD1 (0.67) | OPRD1OPRM1CYP3A4CYP1A2MEN1 | |
| SCHEMBL4575871 | 0.85 | CYP3A4 (0.78) | OPRD1OPRM1CYP3A4CYP1A2MEN1 | |
| SCHEMBL4576004 | 0.84 | OPRD1 (0.56) | OPRD1OPRM1CYP3A4CYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649414-B1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | ARDENT PHARMACEUTICALS INC (US) | 2003-04-16 | — | — | EP | disclosed |
| US-5854249-A | Opioid diarylmethylpiperazines and piperidines | DELTA PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5658908-A | RECEPTOR BINDING SPECIES FOR MEDIATING ANALGESIA, COMBATTING DRUG ADDICTION, DRUG OVERDOSE | DELTA PHARMACEUTICALS, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0649414-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993015062-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-05 | — | — | WO | disclosed |