Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29712083 | 0.71 | — | — | |
| SCHEMBL11135786 | 0.71 | — | — | |
| SCHEMBL21746090 | 0.71 | GAA (0.54) | GAAMAPTALDH1A1POLBPKM | |
| SCHEMBL12411080 | 0.71 | GAA (0.54) | GAAMAPTALDH1A1POLBPKM | |
| SCHEMBL12895544 | 0.71 | MAPT (0.54) | GAAMAPTALDH1A1POLBPKM | |
| SCHEMBL25646850 | 0.71 | MAPT (0.53) | GAAMAPTALDH1A1POLBPKM | |
| SCHEMBL111337 | 0.71 | — | — | |
| SCHEMBL29367162 | 0.71 | — | — | |
| SCHEMBL10877982 | 0.70 | POLB (0.56) | GAAMAPTALDH1A1POLBPKM | |
| Hydrochloric Acid SCHEMBL25247217 | 0.70 | GAA (0.95) | GAAMAPTALDH1A1POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3826679-A1 | COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS | F. Hoffmann-La Roche AG (CH) | 2021-06-02 | — | — | EP | disclosed |
| WO-2020021097-A1 | COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-01-30 | — | — | WO | disclosed |
| EP-2755953-A1 | 3 -PYRIDINE CARBOXYLIC ACID HYDRAZIDES AS HDL-CHOLESTEROL RAISING AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013037703-A1 | 3 -PYRIDINE CARBOXYLIC ACID HYDRAZIDES AS HDL-CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-21 | — | — | WO | disclosed |
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | disclosed |
| EP-0054816-B1 | PROCESS FOR PREPARING N-PYRROLYL-PYRIDAZINEAMINE DERIVATIVES | GRUPPO LEPETIT S.P.A. (IT) | 1985-08-07 | — | — | EP | disclosed |
| US-4385179-A | Process for preparing N-pyrrolyl-pyridazineamine derivatives | GRUPPO LEPETIT S.P.A. (IT) | 1983-05-24 | — | — | US | disclosed |
| EP-0054816-A1 | Process for preparing N-pyrrolyl-pyridazineamine derivatives | GRUPPO LEPETIT S.P.A. (IT) | 1982-06-30 | — | — | EP | disclosed |