Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936956 | 0.90 | SLC6A2 (0.49) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6938759 | 0.89 | SLC6A4 (0.49) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6941381 | 0.89 | SLC6A4 (0.44) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6941054 | 0.89 | SLC6A4 (0.44) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6937031 | 0.88 | SLC6A4 (0.43) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6939180 | 0.88 | SLC6A4 (0.43) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6936991 | 0.87 | SLC6A4 (0.51) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6937437 | 0.87 | LMNA (0.46) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6934477 | 0.86 | SLC6A4 (0.52) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 | |
| SCHEMBL6941665 | 0.85 | OPRM1 (0.44) | OPRM1SLC6A2SLC6A4OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |