Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14528041 | 0.88 | OPRD1 (0.51) | OPRD1OPRM1HPGDALDH1A1MAPT | |
| SCHEMBL3107154 | 0.86 | OPRD1 (0.51) | OPRD1OPRM1HPGDALDH1A1MAPT | |
| SCHEMBL4576604 | 0.85 | ALDH1A1 (0.65) | OPRD1OPRM1HPGDALDH1A1MAPT | |
| SCHEMBL8527824 | 0.85 | HPGD (0.58) | OPRD1OPRM1HPGDALDH1A1MAPT | |
| SCHEMBL4830938 | 0.85 | HPGD (0.54) | OPRD1OPRM1HPGDALDH1A1MAPT | |
| SCHEMBL13620473 | 0.85 | OPRD1 (0.48) | OPRD1OPRM1HPGDALDH1A1MAPT | |
| SCHEMBL1989199 | 0.83 | OPRD1 (0.63) | OPRD1OPRM1 | |
| SCHEMBL10313331 | 0.83 | OPRD1 (0.46) | OPRD1OPRM1HPGDALDH1A1MAPT | |
| SCHEMBL14108185 | 0.82 | OPRD1 (0.48) | OPRD1OPRM1HPGDALDH1A1MAPT | |
| SCHEMBL71266 | 0.81 | OPRD1 (0.54) | OPRD1OPRM1HPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649414-B1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | ARDENT PHARMACEUTICALS INC (US) | 2003-04-16 | — | — | EP | disclosed |
| US-5854249-A | Opioid diarylmethylpiperazines and piperidines | DELTA PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5658908-A | RECEPTOR BINDING SPECIES FOR MEDIATING ANALGESIA, COMBATTING DRUG ADDICTION, DRUG OVERDOSE | DELTA PHARMACEUTICALS, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0649414-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993015062-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-05 | — | — | WO | disclosed |