Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.61 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943134 | 0.89 | DGAT1 (0.58) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL6944995 | 0.82 | MAPT (0.48) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL3111183 | 0.81 | MAPT (1.00) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL3107523 | 0.81 | MAPT (1.00) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL2543291 | 0.81 | MAPT (1.00) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL23355207 | 0.81 | MAPT (0.73) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL8930583 | 0.81 | MAPT (0.81) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL23355483 | 0.80 | MAPT (0.80) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL12240584 | 0.80 | MAPT (0.80) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| SCHEMBL19730460 | 0.80 | MAPT (0.80) | SMN1; SMN2MAPTLMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889881-B1 | NEW TRIAZOLES AS THERAPEUTIC AGENTS FOR FUNGAL INFECTIONS | NAEJA PHARMACEUTICAL INC (CA) | 2003-04-23 | — | — | EP | disclosed |
| US-6153616-A | Triazoles as therapeutic agents for fungal infections | SYNPHAR LABORATORIES, INC. (CA) | 2000-11-28 | — | — | US | disclosed |