Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930768 | 0.81 | MAPK1 (0.77) | MAPK1KMT2AMEN1P2RX7ALDH1A1 | |
| SCHEMBL27514539 | 0.80 | KMT2A (0.50) | MAPK1KMT2AMEN1PDK1PDK2 | |
| SCHEMBL1524902 | 0.78 | P2RX7 (0.73) | CETPP2RX7ALDH1A1LMNATP53 | |
| SCHEMBL30936627 | 0.77 | MAPK1 (0.46) | MAPK1KMT2AMEN1PDK1PDK2 | |
| SCHEMBL1524900 | 0.77 | CETP (0.68) | CETPP2RX7 | |
| SCHEMBL1524592 | 0.77 | CETP (1.00) | CETPP2RX7TP53 | |
| SCHEMBL1524951 | 0.77 | CETP (0.68) | CETPP2RX7 | |
| SCHEMBL993166 | 0.75 | CETP (1.00) | CETPP2RX7 | |
| SCHEMBL8344161 | 0.75 | KMT2A (0.54) | MAPK1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL733777 | 0.74 | KMT2A (0.69) | KMT2AMEN1PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000047-B1 | 1-(N-PHENYLAMINOALKYL)-PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING | RECORDATI CHEM PHARM (CH) | 2003-12-17 | — | — | EP | disclosed |
| CN-1127493-C | 1-(N-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of phenyl ring | RECORDATI CHEM PHARM (CH) | 2003-11-12 | — | — | CN | disclosed |
| US-6399614-B1 | TREATING NEUROMUSCULAR DYSFUNCTION OF LOWER URINARY TRACT VIA PERIPHERAL OR CENTRAL NERVOUS SYSTEM; SEROTONIN RECEPTOR ANTAGONIST | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-04 | — | — | US | disclosed |
| CN-1265654-A | 1-(N-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of phenyl ring | RECORDATI CHEM PHARM (CH) | 2000-09-06 | — | — | CN | disclosed |
| US-6071920-A | BIND TO 5HT 1A RECEPTORS FOR TREATING DISORDERS OF THE LOWER URINARY TRACT; CNS DISORDERS; ANXIOLYTIC AGENTS; ANTIDEPRESSANTS; HYPOTENSIVE AGENTS; SLEEP AND EATING DISORDERS | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2000-06-06 | — | — | US | disclosed |
| EP-1000047-A1 | 1-(N-PHENYLAMINOALKYL)-PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006384-A1 | 1-(N-PHENYLAMINOALKYL)-PIPERAZINE DERIVATIVES SUBSTITUTED AT POSITION 2 OF THE PHENYL RING | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | disclosed |