Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.79 |
| ▸ | HTR1B | P28222 | 13/20 | 0.79 |
| ▸ | MPO | P05164 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945199 | 0.93 | HTR1D (0.72) | HTR1DHTR1BMPO | |
| SCHEMBL6943364 | 0.88 | HTR1D (1.00) | HTR1DHTR1BMPOHTR1AHTR2A | |
| SCHEMBL8781600 | 0.87 | HTR1D (0.74) | HTR1DHTR1B | |
| SCHEMBL8118432 | 0.81 | HTR1D (0.70) | HTR1DHTR1BMPOHTR2A | |
| SCHEMBL8648919 | 0.81 | HTR1D (0.70) | HTR1DHTR1B | |
| SCHEMBL8414664 | 0.81 | HTR1D (0.70) | HTR1DHTR1B | |
| SCHEMBL7480727 | 0.81 | HTR1D (0.70) | HTR1DHTR1B | |
| SCHEMBL6943928 | 0.80 | HTR1D (0.76) | HTR1DHTR1B | |
| SCHEMBL6946024 | 0.80 | HTR1A (0.60) | HTR1DHTR1BMPOHTR1AHTR6 | |
| SCHEMBL8058959 | 0.79 | HTR1D (0.67) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| EP-0925302-A1 | PALLADIUM CATALYZED INDOLIZATION | Merck & Co., Inc. (US) | 1999-06-30 | — | — | EP | claimed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | claimed |
| WO-1998006725-A1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO., INC. (US) | 1998-02-19 | — | — | WO | claimed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | claimed |
| EP-0763032-B1 | PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE | MERCK & CO INC (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | disclosed |