SCHEMBL6946024

SCHEMBL6946024

CCN(CC)CCc1c[nH]c2ccc(Cn3cnnc3)cc12

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 12/20 0.60
HTR2C P28335 6/20 0.60
HTR1D P28221 6/20 0.60
MPO P05164 2/20 0.60
HTR1B P28222 4/20 0.55
HTR2A P28223 3/20 0.55
ADRA2C P18825 1/20 0.55
HRH1 P35367 1/20 0.55
HTR2B P41595 1/20 0.55
HTR6 P50406 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6941530 0.89 HTR1A (0.75) HTR1AHTR2CHTR1DHTR1BHTR2A
SCHEMBL7076434 0.86 HTR1A (0.82) HTR1AHTR2CHTR1DMPOHTR1B
SCHEMBL6939216 0.84 HTR1A (0.65) HTR1AHTR2CHTR1DMPOHTR1B
SCHEMBL7481572 0.82 HTR2C (0.55) HTR1AHTR2CHTR1DHTR1BHTR2A
SCHEMBL6945835 0.81 HTR1A (0.82) HTR1AHTR2CHTR1DMPOHTR1B
SCHEMBL6941388 0.81 HTR1A (0.58) HTR1AHTR2CHTR1DHTR1BHTR2A
SCHEMBL6936730 0.80 HTR1D (0.79) HTR1AHTR1DMPOHTR1BHTR2A
SCHEMBL6941505 0.80 HTR1A (0.57) HTR1AHTR2CHTR1DMPOHTR1B
SCHEMBL27374776 0.80 HTR1A (0.75) HTR1AHTR2CHTR1DMPOHTR1B
SCHEMBL8696560 0.79 MPO (0.51) HTR1AHTR2CHTR1DMPOHTR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0925302-B1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO INC (US) 2002-11-20 EP claimed
EP-0925302-A1 PALLADIUM CATALYZED INDOLIZATION Merck & Co., Inc. (US) 1999-06-30 EP claimed
US-5808064-A HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE MERCK & CO., INC. (US) 1998-09-15 US claimed
WO-1998006725-A1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO., INC. (US) 1998-02-19 WO claimed
US-5567824-A CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR MERCK & CO., INC. (US) 1996-10-22 US claimed
EP-0763032-B1 PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE MERCK & CO INC (US) 2003-10-15 EP disclosed
EP-0925302-B1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO INC (US) 2002-11-20 EP disclosed
EP-0925302-A1 PALLADIUM CATALYZED INDOLIZATION Merck & Co., Inc. (US) 1999-06-30 EP disclosed
US-5808064-A HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE MERCK & CO., INC. (US) 1998-09-15 US disclosed
WO-1998006725-A1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO., INC. (US) 1998-02-19 WO disclosed
US-5567824-A CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR MERCK & CO., INC. (US) 1996-10-22 US disclosed