Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 6/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11077540 | 1.00 | KLK7 (0.48) | KLK7KLK5KDM4EKMT2ALMNA | |
| SCHEMBL13665314 | 0.93 | DPP4 (0.50) | KLK7KLK5NR1H2NR1H3ALDH1A1 | |
| SCHEMBL11078135 | 0.91 | LMNA (0.47) | KLK7KMT2ALMNAMAPK1 | |
| SCHEMBL28466908 | 0.88 | ALDH1A1 (0.47) | KDM4EKMT2ALMNAALDH1A1TSHR | |
| SCHEMBL11078594 | 0.88 | MAPT (0.47) | KDM4EKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL27330497 | 0.88 | ALDH1A1 (0.47) | KDM4EKMT2ALMNAALDH1A1TSHR | |
| SCHEMBL27330978 | 0.85 | ALDH1A1 (0.50) | KDM4EKMT2ALMNAALDH1A1TSHR | |
| SCHEMBL4392704 | 0.83 | PSEN1 (0.58) | KDM4EKMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL27333990 | 0.83 | KDM4E (0.43) | KDM4EKMT2ALMNAALDH1A1MAPK1 | |
| SCHEMBL23459100 | 0.82 | NR1H2 (0.50) | KLK7KLK5NR1H2NR1H3PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907643-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2003-01-15 | — | — | EP | disclosed |
| US-5919777-A | PIPERAZINE DERIVATIVES USEFUL FOR TREATING MEDICAL DISORDERS RESULTING FROM A GROWTH HORMONE DEFIENCY | NOVO NORDISK A/S (DK) | 1999-07-06 | — | — | US | disclosed |
| EP-0907643-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997040023-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1997-10-30 | — | — | WO | disclosed |