Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.68 |
| ▸ | PPARD | Q03181 | 10/20 | 0.68 |
| ▸ | PPARA | Q07869 | 10/20 | 0.68 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933007 | 0.92 | PPARD (0.80) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6933003 | 0.92 | PPARD (0.80) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6933139 | 0.91 | PPARG (0.66) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6935493 | 0.89 | PPARG (0.85) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6936719 | 0.89 | PPARG (0.85) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6937003 | 0.87 | PPARG (0.60) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6933714 | 0.86 | PPARD (0.82) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6932940 | 0.86 | PPARD (0.82) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6932943 | 0.84 | PPARG (0.60) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6937146 | 0.84 | PPARG (0.60) | PPARGPPARDPPARANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | claimed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |