Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197131 | 0.80 | CA1 (0.48) | METAP1EPHX1ALOX5HPGDMETAP2 | |
| SCHEMBL8426469 | 0.79 | ALDH1A1 (0.37) | METAP1EPHX1HPGDMETAP2BMP1 | |
| SCHEMBL9576 | 0.76 | METAP1 (0.46) | METAP1EPHX1ALOX5HPGDMETAP2 | |
| SCHEMBL10801322 | 0.73 | EPHX1 (0.45) | EPHX1ALOX5 | |
| SCHEMBL21540294 | 0.73 | METAP1 (0.55) | METAP1EPHX1ALOX5HPGDMETAP2 | |
| SCHEMBL10305559 | 0.73 | METAP1 (0.55) | METAP1EPHX1ALOX5HPGDMETAP2 | |
| SCHEMBL7349947 | 0.72 | TDP1 (0.35) | EPHX1ALOX5 | |
| SCHEMBL8895135 | 0.72 | TDP1 (0.35) | EPHX1ALOX5 | |
| SCHEMBL6938015 | 0.72 | TDP1 (0.35) | EPHX1ALOX5 | |
| SCHEMBL5378916 | 0.72 | METAP1 (0.48) | METAP1EPHX1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313426-A2 | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1313426-A4 | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2000038618-A2 | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |