Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.35 |
| ▸ | CPN1 | P15169 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895135 | 1.00 | TDP1 (0.35) | TDP1ANPEPENPEPCPN1CPB2 | |
| SCHEMBL7349947 | 1.00 | TDP1 (0.35) | TDP1ANPEPENPEPCPN1CPB2 | |
| SCHEMBL293079 | 0.75 | CA1 (0.39) | TDP1LMNA | |
| SCHEMBL6393775 | 0.75 | CA1 (0.44) | TDP1ANPEPENPEPCPN1CPB2 | |
| SCHEMBL5067338 | 0.74 | TDP1 (0.35) | TDP1ANPEPENPEPALOX5LTA4H | |
| SCHEMBL28601320 | 0.73 | CA1 (0.37) | TDP1LMNA | |
| SCHEMBL22462431 | 0.73 | SMYD3 (0.36) | LTA4H | |
| SCHEMBL6937033 | 0.72 | METAP1 (0.43) | ALOX5EPHX1 | |
| SCHEMBL2188236 | 0.71 | CA2 (0.53) | EPHX1 | |
| SCHEMBL21293263 | 0.71 | ANPEP (0.37) | TDP1ANPEPENPEPCPN1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1268117-A | Novel inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis | DU PONT PHARM CO (US) | 2000-09-27 | — | — | CN | claimed |
| EP-1005448-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | Du Pont Pharmaceuticals Company (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1999009000-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-02-25 | — | — | WO | claimed |
| US-5693619-A | ENZYME INHIBITORS; ADMINISTERED TO TREAT CONGESTIVE HEART FAILURE AND HYPERTENSION | BOEHRINGER INGELHEIM (CANADA), LTD. (CA) | 1997-12-02 | — | — | US | claimed |
| EP-0589445-B1 | Renin Inhibiting N-(2-Amino-2-oxoethyl)Butanediamide Derivatives | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1997-01-15 | — | — | EP | claimed |
| EP-1313426-A2 | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1313426-A4 | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2000038618-A2 | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |
| EP-1005448-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | Du Pont Pharmaceuticals Company (US) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999009000-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |
| US-5554634-A | HYPOTENSIVE | BIO-MEGA BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1996-09-10 | — | — | US | disclosed |
| US-5523315-A | N-(hydroxyethyl)butanediamide derivatives | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1996-06-04 | — | — | US | disclosed |
| CN-1090278-A | Blood vessel tension peptide protoenzyme inhibitor-N-(2-amino-2-oxygen ethyl) succinic diamide derivative | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1994-08-03 | — | — | CN | disclosed |
| CN-1087625-A | N-(hydroxyethyl) succinic diamide derivative | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1994-06-08 | — | — | CN | disclosed |