Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.40 |
| ▸ | FABP7 | O15540 | 2/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872045 | 0.84 | HCAR3 (0.51) | EPHX2KMT2AFABP5FABP7MDM4 | |
| SCHEMBL28552605 | 0.82 | EPHX2 (0.52) | EPHX2KMT2ATP53MDM2 | |
| SCHEMBL21303577 | 0.79 | EPHX2 (0.56) | EPHX2KMT2AFABP5FABP7 | |
| SCHEMBL8366872 | 0.75 | EPHX2 (0.75) | EPHX2KMT2AFABP5FABP7CASP3 | |
| SCHEMBL27644637 | 0.74 | EPHX2 (0.59) | EPHX2KMT2ACASP3 | |
| SCHEMBL15387199 | 0.74 | MDM2 (0.47) | EPHX2KMT2AMDM4TP53CASP3 | |
| SCHEMBL346077 | 0.73 | KMT2A (0.52) | EPHX2KMT2AFABP5FABP7MDM4 | |
| SCHEMBL31370380 | 0.72 | MDM4 (0.49) | MDM4TP53CASP3MDM2 | |
| SCHEMBL25253846 | 0.72 | MDM2 (0.52) | MDM4TP53CASP3MDM2 | |
| SCHEMBL13688459 | 0.72 | KMT2A (0.62) | EPHX2KMT2AFABP5FABP7MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097127-B1 | DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2003-03-12 | — | — | EP | disclosed |
| EP-1097127-A1 | DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003973-A1 | DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |