Hydrocortisone

SCHEMBL6937599

C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	12/20	0.64

▸	HIF1A	Q16665	7/20	0.64

▸	CYP2C19	P33261	2/20	0.64

▸	HSD17B10	Q99714	2/20	0.64

▸	PGR	P06401	2/20	0.64

▸	SERPINA6	P08185	2/20	0.64

▸	CYP3A4	P08684	2/20	0.64

▸	SMN1; SMN2	Q16637	2/20	0.64

▸	NR3C2	P08235	2/20	0.64

▸	KMT2A	Q03164	2/20	0.64

▸	SHBG	P04278	1/20	0.64

▸	MAPT	P10636	1/20	0.64

▸	NFKB1	P19838	1/20	0.64

▸	LMNA	P02545	2/20	0.53

▸	AR	P10275	1/20	0.53

▸	CHRM1	P11229	1/20	0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Cytarabine SCHEMBL27572144	0.82	NR3C1 (0.50)	NR3C1HIF1ACYP2C19HSD17B10PGR
Methylprednisolone SCHEMBL19693042	0.81	NR3C1 (0.65)	NR3C1HIF1ACYP2C19HSD17B10PGR
Hydrocortisone SCHEMBL13202859	0.80	HIF1A (1.00)	NR3C1HIF1ACYP2C19HSD17B10PGR
Hydrocortisone SCHEMBL10292969	0.80	HIF1A (1.00)	NR3C1HIF1ACYP2C19HSD17B10PGR
Hydrocortisone SCHEMBL10261067	0.80	HIF1A (1.00)	NR3C1HIF1ACYP2C19HSD17B10PGR
Hydrocortisone SCHEMBL24900238	0.80	HIF1A (1.00)	NR3C1HIF1ACYP2C19HSD17B10PGR
Hydrocortisone SCHEMBL6370134	0.80	HIF1A (1.00)	NR3C1HIF1ACYP2C19HSD17B10PGR
Hydrocortisone SCHEMBL15114813	0.80	HIF1A (1.00)	NR3C1HIF1ACYP2C19HSD17B10PGR
Hydrocortisone SCHEMBL13046615	0.80	HIF1A (1.00)	NR3C1HIF1ACYP2C19HSD17B10PGR
Hydrocortisone SCHEMBL5699764	0.80	HIF1A (1.00)	NR3C1HIF1ACYP2C19HSD17B10PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1286704-A2	ETHYLENEDICYSTEINE (EC)-DRUG CONJUGATES	Board of Regents, The University of Texas System (US)	2003-03-05	—	—	EP	disclosed
WO-2001091807-A2	ETHYLENEDICYSTEINE (EC)-DRUG CONJUGATES	BOARD OF REGENTS (US)	2001-12-06	—	—	WO	disclosed