Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481262 | 0.77 | PLA2G2A (0.44) | MEN1KMT2APLA2G2ALMNAALDH1A1 | |
| SCHEMBL6937011 | 0.73 | PLA2G2A (0.59) | MEN1KMT2APLA2G2ALMNATSHR | |
| SCHEMBL4414249 | 0.69 | LMNA (0.52) | MEN1KMT2APLA2G2ALMNAALDH1A1 | |
| 5-Phenylvaleric Acid SCHEMBL503601 | 0.64 | MAPT (0.96) | LMNAMAPTRXFP1TSHRSMN1; SMN2 | |
| Formic Acid SCHEMBL6511593 | 0.64 | MAPT (0.85) | LMNAMAPTRXFP1TSHRSMN1; SMN2 | |
| SCHEMBL2553009 | 0.63 | MAPT (1.00) | LMNAMAPTRXFP1TSHRSMN1; SMN2 | |
| SCHEMBL503837 | 0.63 | MAPT (1.00) | LMNAMAPTRXFP1TSHRSMN1; SMN2 | |
| SCHEMBL1008045 | 0.63 | MAPT (1.00) | LMNAMAPTRXFP1TSHRSMN1; SMN2 | |
| SCHEMBL2555645 | 0.63 | MAPT (1.00) | LMNAMAPTRXFP1TSHRSMN1; SMN2 | |
| SCHEMBL770290 | 0.63 | MAPT (1.00) | LMNAMAPTRXFP1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983064-B1 | PYRROLES AS sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-08-06 | — | — | EP | disclosed |
| US-5919774-A | NOVEL COMPOUNDS SUCH AS 2-(1-BENZYL-2,5-DIMETHYL-4-(2-CARBOXYPHENYLMETHYL)PYRROL-3-YL) GLYOXAMIDE FOR INHIBITING HUMAN NONPANCREATIC SECRETORY PHOSPHOLIPASE A2 (SPLA2) MEDIATED RELEASE OF FATTY ACIDS IN A MAMMAL | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |