Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 17/20 | 0.55 |
| ▸ | KCNQ1 | P51787 | 17/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938105 | 1.00 | KCNE1 (0.55) | KCNE1KCNQ1KCNH2CYP3A4MEN1 | |
| SCHEMBL6934962 | 0.84 | KCNE1 (0.75) | KCNE1KCNQ1KCNH2CYP3A4MEN1 | |
| SCHEMBL6935077 | 0.82 | KCNE1 (0.78) | KCNE1KCNQ1KCNH2CYP3A4MEN1 | |
| SCHEMBL6935075 | 0.82 | KCNE1 (0.78) | KCNE1KCNQ1KCNH2CYP3A4MEN1 | |
| SCHEMBL6935190 | 0.82 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2CYP3A4ALOX15 | |
| SCHEMBL6935186 | 0.82 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2CYP3A4ALOX15 | |
| SCHEMBL6932421 | 0.80 | KCNE1 (0.80) | KCNE1KCNQ1KCNH2CYP3A4MEN1 | |
| SCHEMBL6932423 | 0.80 | KCNE1 (0.80) | KCNE1KCNQ1KCNH2CYP3A4MEN1 | |
| SCHEMBL8074810 | 0.71 | KCNE1 (0.52) | KCNE1KCNQ1KCNH2CYP3A4MEN1 | |
| SCHEMBL6602008 | 0.71 | KCNE1 (0.44) | KCNE1KCNQ1KCNH2CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0913396-B1 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| EP-0913396-A2 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-06 | — | — | EP | disclosed |