Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 16/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 16/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601004 | 0.88 | KCNE1 (0.46) | KCNE1KCNQ1MAPTKCNH2KDM4E | |
| SCHEMBL6560005 | 0.85 | KCNE1 (0.43) | KCNE1KCNQ1KCNH2ALDH1A1MEN1 | |
| SCHEMBL6602456 | 0.84 | MAPT (0.39) | KCNE1KCNQ1MAPTKCNH2KDM4E | |
| SCHEMBL6560808 | 0.83 | KCNE1 (0.41) | KCNE1KCNQ1KCNH2TRPV1 | |
| SCHEMBL6559947 | 0.81 | KCNE1 (0.51) | KCNE1KCNQ1KDM4EMEN1CYP1A2 | |
| SCHEMBL6559277 | 0.81 | KCNE1 (0.40) | KCNE1KCNQ1MAPTKCNH2KDM4E | |
| SCHEMBL6559596 | 0.80 | KCNE1 (0.36) | KCNE1KCNQ1 | |
| SCHEMBL6602312 | 0.79 | MAPT (0.35) | KCNE1KCNQ1MAPTKCNH2KDM4E | |
| SCHEMBL6604284 | 0.78 | KCNE1 (0.38) | KCNE1KCNQ1MAPTKDM4EALDH1A1 | |
| SCHEMBL6603457 | 0.78 | KCNE1 (0.66) | KCNE1KCNQ1MAPTKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906911-B1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6177449-B1 | CARDIOVASCULAR DISORDERS; ANTIULCER AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-23 | — | — | US | disclosed |
| EP-0906911-A1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-07 | — | — | EP | disclosed |