Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 10/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214436 | 0.84 | KMT2A (0.52) | PTGER1STAT3KMT2A | |
| SCHEMBL8676962 | 0.83 | ELANE (0.52) | PTGER1KMT2AHTR1ADRD2 | |
| SCHEMBL4720836 | 0.83 | PTGER1 (0.56) | PTGER1STAT3SLC6A4 | |
| SCHEMBL2954443 | 0.81 | MAPT (0.60) | PTGER1 | |
| SCHEMBL1196687 | 0.81 | CCR5 (0.64) | PTGER1STAT3KMT2ASLC6A4 | |
| SCHEMBL562155 | 0.81 | PTGER1 (0.55) | PTGER1STAT3SLC6A4 | |
| SCHEMBL2214441 | 0.81 | PTGER1 (0.53) | PTGER1STAT3KMT2A | |
| SCHEMBL4268295 | 0.80 | HTR1A (0.73) | PTGER1KMT2AHTR1ADRD2 | |
| SCHEMBL30557975 | 0.80 | PTGER1 (0.54) | PTGER1STAT3SLC6A4 | |
| Hydrochloric Acid SCHEMBL6214742 | 0.80 | CCR5 (0.62) | PTGER1STAT3KMT2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421834-A1 | PYRAZOLE AND TRIAZOLE CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | Glaxo Group Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122088-A1 | PYRAZOLE AND TRIAZOLE CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | GLAXO GROUP LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |